Invention Grant
US08829010B2 Pyrazolo[3,4-d]pyrimidine compounds and their use as PDE2 inhibitors and/or CYP3A4 inhibitors
有权
吡唑并[3,4-d]嘧啶化合物及其作为PDE2抑制剂和/或CYP3A4抑制剂的用途
- Patent Title: Pyrazolo[3,4-d]pyrimidine compounds and their use as PDE2 inhibitors and/or CYP3A4 inhibitors
- Patent Title (中): 吡唑并[3,4-d]嘧啶化合物及其作为PDE2抑制剂和/或CYP3A4抑制剂的用途
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Application No.: US14116064Application Date: 2012-05-24
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Publication No.: US08829010B2Publication Date: 2014-09-09
- Inventor: Christopher John Helal , Thomas Allen Chappie , John Michael Humphrey
- Applicant: Christopher John Helal , Thomas Allen Chappie , John Michael Humphrey
- Applicant Address: US NY New York
- Assignee: Pfizer Inc.
- Current Assignee: Pfizer Inc.
- Current Assignee Address: US NY New York
- Agent Feng Shao
- International Application: PCT/IB2012/052627 WO 20120524
- International Announcement: WO2012/168817 WO 20121213
- Main IPC: C07D487/04
- IPC: C07D487/04 ; A61K31/519
![Pyrazolo[3,4-d]pyrimidine compounds and their use as PDE2 inhibitors and/or CYP3A4 inhibitors](/abs-image/US/2014/09/09/US08829010B2/abs.jpg.150x150.jpg)
Abstract:
The present invention provides, inter alia, compounds of Formula (I) and pharmaceutically acceptable salts thereof, to processes for the preparation of, intermediates used in the preparation of, and compositions containing such compounds and the uses of such compounds as a method for the treatment of a disease or condition selected from the group consisting of central nervous system disorders, cognitive disorders, schizophrenia, dementia and other disorders in a mammal. The present invention further provides compounds of Formula (Id) and pharmaceutically acceptable salts thereof as CYP3A4 selective inhibitors.
Public/Granted literature
- US20140080806A1 PYRAZOLO[3,4-D]PYRIMIDINE COMPOUNDS AND THEIR USE AS PDE2 INHIBITORS AND/OR CYP3A4 INHIBITORS Public/Granted day:2014-03-20
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