Invention Grant
- Patent Title: Stable tablet containing 4,5-epoxymorphinan derivative
- Patent Title (中): 含有4,5-环氧吗啡喃衍生物的稳定片剂
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Application No.: US13125726Application Date: 2009-10-23
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Publication No.: US08829019B2Publication Date: 2014-09-09
- Inventor: Kotoe Ohta , Suguru Takaki , Yasuhide Horiuchi
- Applicant: Kotoe Ohta , Suguru Takaki , Yasuhide Horiuchi
- Applicant Address: JP Tokyo
- Assignee: Toray Industries, Inc.
- Current Assignee: Toray Industries, Inc.
- Current Assignee Address: JP Tokyo
- Agency: Birch, Stewart, Kolasch & Birch, LLP
- Priority: JP2008-274579 20081024
- International Application: PCT/JP2009/068228 WO 20091023
- International Announcement: WO2010/047381 WO 20100429
- Main IPC: A61K31/44
- IPC: A61K31/44 ; A61K9/00 ; A61K9/16 ; A61K9/20 ; A61K31/485

Abstract:
The present invention relates to a stable tablet comprising a 4,5-epoxymorphinan derivative or a pharmacologically acceptable acid addition salt thereof as an effective ingredient. That is, the tablet according to the present invention comprises: (1) as the effective ingredient, a specific 4,5-epoxymorphinan derivative or a pharmacologically acceptable acid addition salt; (2) sodium thiosulfate; (3) at least one selected from the group consisting of saccharides and sugar alcohols; and (4) crospovidone, sodium carboxymethyl starch or a mixture thereof, in which tablet the content of the aforementioned (4) is 1 to 20% by weight per unit weight containing the aforementioned effective ingredient.
Public/Granted literature
- US20120114752A1 STABLE TABLET CONTAINING 4,5-EPOXYMORPHINAN DERIVATIVE Public/Granted day:2012-05-10
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