Invention Grant
US08829023B2 Process for obtaining compounds derived from tetrahydro-β-carboline
有权
获得衍生自四氢 - 咔啉的化合物的方法
- Patent Title: Process for obtaining compounds derived from tetrahydro-β-carboline
- Patent Title (中): 获得衍生自四氢 - 咔啉的化合物的方法
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Application No.: US13984458Application Date: 2012-02-10
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Publication No.: US08829023B2Publication Date: 2014-09-09
- Inventor: Xavier Berzosa Rodríguez , Francisco Marquillas Olondriz
- Applicant: Xavier Berzosa Rodríguez , Francisco Marquillas Olondriz
- Applicant Address: ES Sant Cugat del Vallès
- Assignee: Interquim, S.A.
- Current Assignee: Interquim, S.A.
- Current Assignee Address: ES Sant Cugat del Vallès
- Agency: Birch, Stewart, Kolasch & Birch, LLP
- Priority: ES201130177 20110210
- International Application: PCT/EP2012/052281 WO 20120210
- International Announcement: WO2012/107549 WO 20120816
- Main IPC: A01N43/42
- IPC: A01N43/42 ; A61K31/44 ; C07D221/18 ; C07D471/00 ; C07D498/00 ; C07D515/00 ; C07D221/22 ; C07D221/06 ; C07D491/00 ; C07D471/14 ; C07D471/04
Abstract:
The invention relates to a process for obtaining compounds derived from tetrahydro-β-carboline, specifically tadalafil and intermediate products from the synthesis, comprising the reaction between piperonal and an alkyl ester of D-tryptophan as a salt, and in the absence of any other component, followed by haloacetylation and a final cyclization with methylamine.
Public/Granted literature
- US20130324730A1 PROCESS FOR OBTAINING COMPOUNDS DERIVED FROM TETRAHYDRO-beta-CARBOLINE Public/Granted day:2013-12-05
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