Invention Grant
US08829051B2 Method of treating or preventing pathologic effects of acute increases in hyperglycemia and/or acute increases of free fatty acid flux
有权
治疗或预防高血糖急性增加和/或游离脂肪酸通量急剧升高的病理作用的方法
- Patent Title: Method of treating or preventing pathologic effects of acute increases in hyperglycemia and/or acute increases of free fatty acid flux
- Patent Title (中): 治疗或预防高血糖急性增加和/或游离脂肪酸通量急剧升高的病理作用的方法
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Application No.: US11136254Application Date: 2005-05-24
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Publication No.: US08829051B2Publication Date: 2014-09-09
- Inventor: Geoffrey C. Gurtner , Michael A. Brownlee
- Applicant: Geoffrey C. Gurtner , Michael A. Brownlee
- Applicant Address: US CA Stanford
- Assignee: Geoffrey C. Gurtner
- Current Assignee: Geoffrey C. Gurtner
- Current Assignee Address: US CA Stanford
- Agency: Medlen & Carroll, LLP
- Main IPC: A61K31/13
- IPC: A61K31/13 ; A61K31/19 ; A61K31/385 ; A61K31/555 ; A61K31/198
Abstract:
One aspect of the present invention relates to a method of treating or preventing pathologic sequelae of acute hyperglycemia and/or increased fatty acid flux in a subject. This method involves administering an ROS inhibitor to the subject. In addition, methods of promoting neovascularization, inhibiting oxidation or excessive release of free fatty acids, and identifying compounds suitable for treatment or prevention of ROS-mediated injury are also disclosed.
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