Invention Grant
US08829190B2 Triazolopyridines as phosphodiesterase inhibitors for treatment of dermal diseases
有权
三唑并吡啶类作为治疗皮肤疾病的磷酸二酯酶抑制剂
- Patent Title: Triazolopyridines as phosphodiesterase inhibitors for treatment of dermal diseases
- Patent Title (中): 三唑并吡啶类作为治疗皮肤疾病的磷酸二酯酶抑制剂
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Application No.: US12595922Application Date: 2008-04-16
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Publication No.: US08829190B2Publication Date: 2014-09-09
- Inventor: Jakob Felding , Morten Dahl Sørensen
- Applicant: Jakob Felding , Morten Dahl Sørensen
- Applicant Address: DK Ballerup
- Assignee: Leo Pharma A/S
- Current Assignee: Leo Pharma A/S
- Current Assignee Address: DK Ballerup
- Agency: Birch Stewart, Kolasch & Birch, LLP
- International Application: PCT/DK2008/000135 WO 20080416
- International Announcement: WO2008/125111 WO 20081023
- Main IPC: C07D471/04
- IPC: C07D471/04 ; A61K31/437

Abstract:
The present invention relates to a compound according to formula (I), wherein X and Y are either C and N or N and C; Z is CH2, CH2—CH2, CH2—NH, or NH; R1 is halogen, or R1 is alkyl, alkenyl, alkynyl, haloalkyl, alkoxy, cycloalkyl, alkoxycarbonyl, aryl, all of which are optionally substituted; R2 is hydrogen, or R2 is alkyl, cycloalkyl, alkoxy, heterocycloalkyl, aryl, heteroaryl, alkoxycarbonyl, aminocarbonyl, amino, all of which are optionally substituted; A is aryl, cycloalkyl, cycloalkenyl, heteroaryl, heterocycloalkyl or heterocycloalkenyl, all of which are optionally substituted; and pharmaceutically acceptable salts, hydrates, or solvates hereof. The invention further relates to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds, to methods of treating diseases, e.g. dermal diseases, with said compounds, and to the use of said compounds in the manufacture of medicaments, in particular for the treatment of dermal diseases.
Public/Granted literature
- US20100113442A1 TRIAZOLOPYRIDINES AS PHOSPHODIESTERASE INHIBITORS FOR TREATMENT OF DERMAL DISEASES Public/Granted day:2010-05-06
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