Invention Grant
US08829208B2 Process for the preparation of darunavir and darunavir intermediates
有权
制备地瑞那韦和地瑞那韦中间体的方法
- Patent Title: Process for the preparation of darunavir and darunavir intermediates
- Patent Title (中): 制备地瑞那韦和地瑞那韦中间体的方法
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Application No.: US13519297Application Date: 2011-01-24
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Publication No.: US08829208B2Publication Date: 2014-09-09
- Inventor: Michael Mizhiritskii , Ehud Marom
- Applicant: Michael Mizhiritskii , Ehud Marom
- Applicant Address: IL Ness Ziona
- Assignee: Mapi Pharma Ltd.
- Current Assignee: Mapi Pharma Ltd.
- Current Assignee Address: IL Ness Ziona
- Agency: Rothwell, Figg, Ernst & Manbeck, P.C.
- Priority: WOPCT/IL2010/000533 20100701
- International Application: PCT/IL2011/000079 WO 20110124
- International Announcement: WO2011/092687 WO 20110804
- Main IPC: C07D493/04
- IPC: C07D493/04
Abstract:
The present invention relates to a process for the preparation of darunavir, a nonpeptide protease inhibitor (PI), useful for the treatment of HIV/AIDS patients harboring multidrug-resistant HIV-1 variants that do not respond to previously existing HAART regimens. The present invention further relates to processes for the stereo-directed preparation of darunavir intermediates, in particular (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol and to certain novel intermediates obtained by such processes.
Public/Granted literature
- US20120296101A1 PROCESS FOR THE PREPARATION OF DARUNAVIR AND DARUNAVIR INTERMEDIATES Public/Granted day:2012-11-22
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