A multi-channel isolation system has N+1 isolators for N channels of communication data. N of the isolators may transfer data signals across an isolation barrier, one for each of the N channels of data. An N+1st isolator transfers refresh signals representing state of the data signals on the N isolators. Receiver circuitry, therefore, may receive signals from the N isolation channels without risk for collision with refresh signals. If reception of the refresh signals becomes necessary, circuitry on a receive side of the isolator may switch over to the N+1st receive path to output state data contained in the refresh signals.