Methods and apparatus to mitigate interference among multiple wireless subsystems of a wireless communication device are described. A host processor obtains configurations for a plurality of wireless subsystems and evaluates whether potential or actual coexistence interference exists between two or more of the wireless subsystems. The host processor provides configuration information and link quality reporting parameters to and obtains link quality reports from at least two wireless subsystems. When link quality for at least one wireless subsystem fails a set of link quality conditions, the host processor adjusts data requirements for applications that communicate through one or more of the wireless subsystems and/or adjusts radio frequency operating conditions for one or more of the wireless subsystems to mitigate interference among the wireless subsystems.