A nuclear probe and ultrasound transducer are interconnected, such as being in a same hand-held housing. The interconnection aligns the coordinate systems in a known spatial relationship. The ultrasound data is used to detect transducer offset or change in position without a tracking sensor. The radiation detected by the nuclear probe may be reconstructed into an image based on the detected transducer position since the nuclear probe moves with the ultrasound transducer. Both anatomical and functional imaging may be provided together without the complications of calibration and tracking. Where a therapeutic transducer is included, therapy may also be provided. The anatomical and functional information identifies the regions for treatment. The same device, already positioned correctly based on the functional and anatomical imaging, is then used for treatment with high intensity focused ultrasound.