An e-mail sender is provided with an option to send a notification to the prospective recipient(s) of an e-mail indicating to the recipient that an e-mail has been sent to his or her attention or to a business or other entities attention. The notification can be advantageously sent by a different communications route, such as by mail, courier, telephone call, facsimile, social network, or other method. Back up notifications can also be sent on an automated basis. The notification can be sent automatically and/or sent a period of time after the e-mail is sent if an acknowledgment or reply is not received.