In embodiments of a high-speed I/O data system, a first computer chip includes a data transmission system, and a second computer chip includes a data reception system. A data channel communicates an NRZ data signal, and a clock channel communicates a forwarded clock signal, from the data transmission system to the data reception system. The data transmission system includes a first differential serializing transmitter to generate the NRZ data signal from pulsed data, and further includes a second differential serializing transmitter to generate a forwarded clock signal. A first multi-phase transmit clock generator generates transmit clock signals for the first and second differential serializing transmitters. The data reception system includes a data receiver and a de-serializer to receive and de-serialize the NRZ data signal, and includes a multi-phase receive clock generator to generate receive clock signals from the forwarded clock signal for the de-serializing data receiver.