A screw syringe having a piston spindle with an external thread, a syringe barrel, having a sleeve with a piston end, and a female part with an internal thread is disclosed. The female part slides onto the piston end. The female part has a flange that creates a form fit with a counter-surface at the piston end so axial displacement of the female part in relation to the syringe barrel in the discharge direction is prevented. The female part has retaining surfaces that create a form fit with counter-retaining surfaces of the piston end, thereby preventing axial displacement of the female part in relation to the syringe barrel counter to the discharge direction. The retaining surfaces and counter-retaining surfaces create a form fit that prevents radial relative movement between the retaining surfaces and the counter-retaining surfaces, directed perpendicularly to the sliding direction.