Invention Grant
US08834866B2 Methods and compositions for treatment of myotubular myopathy using chimeric polypeptides comprising myotubularin 1(MTM1) polypeptides
有权
使用包含myotubularin 1（MTM1）多肽的嵌合多肽治疗肌管肌病的方法和组合物
- Patent Title: Methods and compositions for treatment of myotubular myopathy using chimeric polypeptides comprising myotubularin 1(MTM1) polypeptides
- Patent Title (中): 使用包含myotubularin 1（MTM1）多肽的嵌合多肽治疗肌管肌病的方法和组合物
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Application No.: US13378283Application Date: 2010-06-15
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Publication No.: US08834866B2Publication Date: 2014-09-16
- Inventor: Dustin D. Armstrong
- Applicant: Dustin D. Armstrong
- Applicant Address: US MA Concord
- Assignee: Valerion Therapeutics, LLC
- Current Assignee: Valerion Therapeutics, LLC
- Current Assignee Address: US MA Concord
- Agency: Ropes & Gray LLP
- International Application: PCT/US2010/038703 WO 20100615
- International Announcement: WO2010/148010 WO 20101223
- Main IPC: C12N9/96
- IPC: C12N9/96 ; C12N9/00
Abstract:
The present invention provides chimeric polypeptides comprising myotubularin 1 (MTMI) polypeptides and an internalising moiety, wherein, the moiety can be an antibody, and is preferably monoclonal antibody 3E10, a functional variant or a fragment thereof. One aspect of the present invention provides compositions comprising these chimeric polypeptides together with a pharmaceutically acceptable carrier, and optionally, a further therapeutic agent. Another aspect of the present invention provides methods of treating Myotubular Myopathy comprising administering the polypeptides or compositions comprising the polypeptides to a subject in need.
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