Invention Grant
- Patent Title: Notch1 binding agents and methods of use thereof
- Patent Title (中): Notch1结合剂及其使用方法
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Application No.: US13005966Application Date: 2011-01-13
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Publication No.: US08834875B2Publication Date: 2014-09-16
- Inventor: Edward Thein Htun Van Der Horst
- Applicant: Edward Thein Htun Van Der Horst
- Applicant Address: US CA Redwood City
- Assignee: OncoMed Pharmaceuticals, Inc.
- Current Assignee: OncoMed Pharmaceuticals, Inc.
- Current Assignee Address: US CA Redwood City
- Agency: Sterne, Kessler, Goldstein & Fox P.L.L.C.
- Main IPC: A61K39/395
- IPC: A61K39/395 ; A61P35/02 ; C07K16/30 ; C07K16/28 ; A61K39/00
Abstract:
The present invention relates to Notch1 binding agents and methods of using the agents for treating diseases, such as hematologic cancers. The present invention provides antibodies that specifically bind to a non-ligand binding membrane proximal region of the extracellular domain of human Notch1. The present invention further provides methods of using agents that inhibit Notch1 activity for treating cancer. Also described are methods of treating hematologic cancers comprising administering a therapeutically effective amount of a binding agent or antibody of the present invention to a subject having a hematologic cancer such as T-cell lymphoblastic leukemia.
Public/Granted literature
- US20120213786A1 Notch1 Binding Agents and Methods of Use Thereof Public/Granted day:2012-08-23
Information query
