Invention Grant
US08834924B2 Immediate release formulations of 1-aminocyclohexane compounds, memantine and neramexane
有权
1-氨基环己烷化合物,美金刚和neramexane的即时释放配方
- Patent Title: Immediate release formulations of 1-aminocyclohexane compounds, memantine and neramexane
- Patent Title (中): 1-氨基环己烷化合物,美金刚和neramexane的即时释放配方
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Application No.: US13134467Application Date: 2011-06-08
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Publication No.: US08834924B2Publication Date: 2014-09-16
- Inventor: Yan Yang , Rajiv Janjikhel , Niranjan Rao , Antonia Periclou , Wattanaporn Abramowitz , Mahendra G. Dedhiya , Erhard Seiller , Bernhard Hauptmeier
- Applicant: Yan Yang , Rajiv Janjikhel , Niranjan Rao , Antonia Periclou , Wattanaporn Abramowitz , Mahendra G. Dedhiya , Erhard Seiller , Bernhard Hauptmeier
- Applicant Address: BM Hamilton
- Assignee: Forest Laboratories Holdings Limited
- Current Assignee: Forest Laboratories Holdings Limited
- Current Assignee Address: BM Hamilton
- Agency: Hueschen and Sage
- Main IPC: A61K9/20
- IPC: A61K9/20 ; A61K9/28 ; A61K31/13

Abstract:
The present invention relates to an immediate release solid oral dosage form containing 1-aminocyclohexanes, preferably memantine or neramexane, and optionally a pharmaceutically acceptable coating, wherein the active ingredient exhibits dose proportionality and is released at a dissolution rate of more than about 80% within about the first 60 minutes following entry of said form into a use environment. The dosage form is direct compressed and has a hardness within the range of between about 3 and about 40 Kp, exhibits an average Tmax within the range of about 2 to about 8 hours with an active ingredient load within the range of about 2.5 to about 150 mg. The formulation allows for dose-proportional compositions for once daily or b.i.d. dosing, while maintaining a steady average range of Tmax.
Public/Granted literature
- US20110236439A1 Immediate release formulations of 1-aminocyclohexane compounds, memantine and neramexane Public/Granted day:2011-09-29
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