Invention Grant
- Patent Title: Macromolecular diffusion and release from self-assembled β-hairpin peptide hydrogels
- Patent Title (中): 大分子扩散和释放自组装和毛发肽水凝胶
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Application No.: US12533708Application Date: 2009-07-31
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Publication No.: US08834926B2Publication Date: 2014-09-16
- Inventor: Joel P. Schneidér , Monica C. Branco , Darrin J. Pochan , Norman J. Wagner
- Applicant: Joel P. Schneidér , Monica C. Branco , Darrin J. Pochan , Norman J. Wagner
- Applicant Address: US DE Newark
- Assignee: University of Delaware
- Current Assignee: University of Delaware
- Current Assignee Address: US DE Newark
- Agency: RatnerPrestia
- Main IPC: A61K9/06
- IPC: A61K9/06 ; A61K38/10 ; A61K38/16 ; A61K9/00 ; A61K47/36
Abstract:
A hydrogel for delayed release of an anionic macromolecule, wherein the hydrogel comprises the anionic macromolecule, 150 mM NaCl, and a peptide selected from the group consisting of SEQ ID NO:1 through SEQ ID NO:33 in an aqueous medium at a pH of 7.4; wherein the anionic macromolecule has an isoelectric point of at most 6.8; and wherein the hydrogel is capable of retaining at least 25% of the anionic macromolecule after 28-day extraction at 37° C. with a pH=7.4 BTP buffer containing 150 mM NaCl.
Public/Granted literature
- US20100034881A1 MACROMOLECULAR DIFFUSION AND RELEASE FROM SELF-ASSEMBLED BETA-HAIRPIN PEPTIDE HYDROGELS Public/Granted day:2010-02-11
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