Invention Grant
- Patent Title: Compounds of the pterocarpanquinone family, method for preparing the same, pharmaceutical composition containing the new compounds of the pterocarpanquinone family, uses and therapeutic method
- Patent Title (中): 皮蔻烷醌系的化合物，其制备方法，含有皮癣苯醌类新化合物的药物组合物，用途及治疗方法
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Application No.: US13127797Application Date: 2009-11-05
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Publication No.: US08835489B2Publication Date: 2014-09-16
- Inventor: Alcides Jose Monteiro Da Silva , Vivian Mary Barral Dold Rumjanek , Bartira Rossi Bergmann , Eduardo Salustiano Jesus Dos Santos , Paulo Roberto Ribeiro Costa , Chaquip Daher Netto , Wallace Pacienza Lima , Eduardo Caio Torres Dos Santos , Moises Clemente Marinho Cavalcante , Sergio Henrique Seabra , Ingred Goretti Rica
- Applicant: Alcides Jose Monteiro Da Silva , Vivian Mary Barral Dold Rumjanek , Bartira Rossi Bergmann , Eduardo Salustiano Jesus Dos Santos , Paulo Roberto Ribeiro Costa , Chaquip Daher Netto , Wallace Pacienza Lima , Eduardo Caio Torres Dos Santos , Moises Clemente Marinho Cavalcante , Sergio Henrique Seabra , Ingred Goretti Rica
- Applicant Address: BR Rio de Janeiro
- Assignee: Universidade Federal Do Rio de Janeiro
- Current Assignee: Universidade Federal Do Rio de Janeiro
- Current Assignee Address: BR Rio de Janeiro
- Agency: Fildes & Outland, P.C.
- Priority: BRPI0806047-9 20081106
- International Application: PCT/BR2009/000364 WO 20091105
- International Announcement: WO2010/054452 WO 20100520
- Main IPC: A61K31/35
- IPC: A61K31/35 ; C07D311/94 ; C07D493/04
Abstract:
This invention belongs to the chemical-pharmaceutical field. New compounds of pterocarpanquinone family presented in formula (I) according to this invention are capable to be activated by reduction generating alkylating species intracellularly. It presents selective cytotoxic effects particularly on mammalian human and nonhuman cells that divide constantly and are useful in treating diseases and dysfunctions related to the phenomenon of undesired cell proliferation. Such compounds are also effective for the treatment of diseases or dysfunctions related to high levels of TNF-α in human and nonhuman mammals.
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