Invention Grant
- Patent Title: Process for the preparation of intermediates for the manufacture of NEP inhibitors
- Patent Title (中): 制备NEP抑制剂中间体的方法
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Application No.: US13818507Application Date: 2011-08-22
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Publication No.: US08835668B2Publication Date: 2014-09-16
- Inventor: David Hook , Jianguang Zhou , Yunzhong Li
- Applicant: David Hook , Jianguang Zhou , Yunzhong Li
- Applicant Address: CH Basel
- Assignee: Novartis AG
- Current Assignee: Novartis AG
- Current Assignee Address: CH Basel
- Agent Matthew Mulkeen
- Priority: WOPCT/CN2010/076245 20100823
- International Application: PCT/EP2011/064410 WO 20110822
- International Announcement: WO2012/025501 WO 20120301
- Main IPC: C07C209/68
- IPC: C07C209/68 ; C07C269/06
Abstract:
The invention relates to a new process for producing useful intermediates for the manufacture of NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a γ-amino-δ-biphenyl-α-methylalkanoic acid, or acid ester, backbone, such as N-(3-carboxyl-1-oxopropyl)-(4S)-(p-phenylphenylmethyl)-4-amino-(2R)-methyl butanoic acid ethyl ester or salt thereof.
Public/Granted literature
- US20130158285A1 PROCESS FOR THE PREPARATION OF INTERMEDIATES FOR THE MANUFACTURE OF NEP INHIBITORS Public/Granted day:2013-06-20
Information query
