Invention Grant
- Patent Title: Manufacture of a triiodinated contrast agent
- Patent Title (中): 制造三碘化造影剂
-
Application No.: US14128782Application Date: 2012-02-02
-
Publication No.: US08835672B2Publication Date: 2014-09-16
- Inventor: Jose Manuel Galindro , Ana Cristina Cruz , João José Bandarra , William Heggie
- Applicant: Jose Manuel Galindro , Ana Cristina Cruz , João José Bandarra , William Heggie
- Applicant Address: CH Lucerne
- Assignee: Hovione Inter Limited
- Current Assignee: Hovione Inter Limited
- Current Assignee Address: CH Lucerne
- Agency: MacMillan, Sobanski & Todd, LLC
- Priority: PT105770 20110624
- International Application: PCT/GB2012/000109 WO 20120202
- International Announcement: WO2012/175903 WO 20121227
- Main IPC: C07C67/02
- IPC: C07C67/02 ; C07C233/00 ; C07C231/18 ; C07C231/24 ; C07C231/02 ; C07C235/16

Abstract:
A new compound, (S)-5-(2-acetoxypropanamido)-2,4,6-triiodoisophthalic acid, of formula II (S)-5-(2-acetoxypropanamido)-2,4,6-triiodoisophthalic acid. Said new compound is of use for the production of triiodinated contrast agent, especially lopamidol, with low content of acetyl and hydroxyacetyl analogs. The new compound may be formed from 5-amino-2,4,6-triiodoisophtalic acid by acylating with (S)-1-chloro-1-oxopropan-2-yl acetate. The new compound may then be converted to the respective acid dichloride by reacting with a chlorinating reagent, which is a further object of the present invention, followed by the amidation with 2-amino-1,3-propanediol and acetate hydrolysis.
Public/Granted literature
- US20140155648A1 Manufacture of a Triiodinated Contrast Agent Public/Granted day:2014-06-05
Information query