In a PWM signal generation method of a voltage regulator, an output sense signal, a first ramp signal and a second ramp signal are provided. A first time point of the first ramp signal crossing with the output sense signal is used to determine a start point of an ON-time of a PWM signal, and a second time point of the second ramp signal crossing with the output sense signal is used to determine an end point of the ON-time of the PWM signal. Moreover, the first ramp signal is reset to a reference voltage at the first time point and then maintained at the reference voltage, and further ramps down starting from the end point of the ON-time. The second ramp signal ramps up starting from the start point of the ON-time, and then is reset to a preset voltage at the second time point.