A high-strength panel anchoring system for use in a cavity wall. A wall anchor is fixedly attached to an inner wythe. The wall anchor includes a set of pronged legs for insertion through insulation and securement against the inner wythe and a plate connecting the set of pronged legs and maintaining the legs at substantially right angles from the plate. The plate has an aperture to receive a fastener. A U-shaped separator is adjacent the wall anchor. A split veneer tie is adjacent the separator and opposite the wall anchor. The veneer tie includes a backplate having an aperture to receive a fastener and an insertion portion having a cavity end contiguous with the backplate and set at a substantially right angle thereto. The insertion portion has an insertion end having two legs set at opposite substantially right angles for interconnection with a plurality of panels forming an outer wythe.