A climate control system of a vehicle and a method of controlling the climate control system to minimize vehicle energy consumption and maximize occupant comfort. The climate control system includes a main HVAC system for conditioning a fluid discharged into a passenger compartment of the vehicle, an auxiliary HVAC system for conditioning a localized fluid of at least one HVAC zones of the passenger compartment, a seat system, and an HVAC controller. The HVAC controller controls the main HVAC system, the auxiliary HVAC system, and the seat system based upon at least one parameter and condition which pertains to at least one of electrical energy consumption of the vehicle and occupant comfort.