Invention Grant
- Patent Title: Viral/bacterial toxin polypeptides and methods of using same
- Patent Title (中): 病毒/细菌毒素多肽及其使用方法
-
Application No.: US12065066Application Date: 2006-08-30
-
Publication No.: US08841253B2Publication Date: 2014-09-23
- Inventor: John R. Murphy , Ryan Ratts
- Applicant: John R. Murphy , Ryan Ratts
- Applicant Address: US MA Boston
- Assignee: Boston Medical Center Corporation
- Current Assignee: Boston Medical Center Corporation
- Current Assignee Address: US MA Boston
- Agency: Clark & Elbing LLP
- Agent Todd Armstrong
- International Application: PCT/US2006/033830 WO 20060830
- International Announcement: WO2007/126415 WO 20071108
- Main IPC: A61K38/08
- IPC: A61K38/08

Abstract:
The invention features methods for identifying compounds that inhibit cell death, and methods for identifying compounds that promote cell death, by blocking or accelerating, respectively, the translocation of the catalytic domain of toxins or transcription factors through the endosomal membrane into the cytosol of a cell. Also featured are methods for inhibiting cell death that include the administration of polypeptides that include a toxin consensus sequence recognized by one or more components of the cytosolic translocation factor complex.
Public/Granted literature
- US20080306003A1 Novel Compositions and Methods for Promoting, Inhibiting and Detecting Protein Entry Into Cells Public/Granted day:2008-12-11
Information query
IPC分类: