Invention Grant
US08841253B2 Viral/bacterial toxin polypeptides and methods of using same 有权
病毒/细菌毒素多肽及其使用方法

Viral/bacterial toxin polypeptides and methods of using same
Abstract:
The invention features methods for identifying compounds that inhibit cell death, and methods for identifying compounds that promote cell death, by blocking or accelerating, respectively, the translocation of the catalytic domain of toxins or transcription factors through the endosomal membrane into the cytosol of a cell. Also featured are methods for inhibiting cell death that include the administration of polypeptides that include a toxin consensus sequence recognized by one or more components of the cytosolic translocation factor complex.
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