Invention Grant
US08841408B2 Macromonomers and hydrogel systems using native chemical ligation, and their methods of preparation
有权
使用天然化学连接的大分子单体和水凝胶体系及其制备方法
- Patent Title: Macromonomers and hydrogel systems using native chemical ligation, and their methods of preparation
- Patent Title (中): 使用天然化学连接的大分子单体和水凝胶体系及其制备方法
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Application No.: US12106429Application Date: 2008-04-21
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Publication No.: US08841408B2Publication Date: 2014-09-23
- Inventor: Phillip B Messersmith , Bi-Huang Hu , Jing Su
- Applicant: Phillip B Messersmith , Bi-Huang Hu , Jing Su
- Applicant Address: US IL Evanston
- Assignee: Northwestern University
- Current Assignee: Northwestern University
- Current Assignee Address: US IL Evanston
- Agency: Quarles & Brady, LLP
- Main IPC: C08G69/06
- IPC: C08G69/06 ; C08G69/40 ; C08G69/02 ; C08G69/04 ; C08G69/08
Abstract:
Biocompatible macromonomers, hydrogels, methods of synthesis and methods of use thereof are provided. The biocompatible hydrogels of the present invention are prepared using native chemical ligation (NCL), in which a thioester readily reacts with a N-terminal thiol (cysteine) through transesterification and rearrangement to form an amide bond through a five-member ring intermediate.
Public/Granted literature
- US20080274980A1 MACROMONOMERS AND HYDROGEL SYSTEMS USING NATIVE CHEMICAL LIGATION, AND THEIR METHODS OF PREPARATION Public/Granted day:2008-11-06
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