Invention Grant
- Patent Title: Human androgen receptor alternative splice variants
- Patent Title (中): 人类雄激素受体替代剪接变体
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Application No.: US13403029Application Date: 2012-02-23
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Publication No.: US08841422B2Publication Date: 2014-09-23
- Inventor: Yun Qiu , Zhiyong Guo , Xi Yang
- Applicant: Yun Qiu , Zhiyong Guo , Xi Yang
- Applicant Address: US MD Baltimore
- Assignee: University of Maryland, Baltimore
- Current Assignee: University of Maryland, Baltimore
- Current Assignee Address: US MD Baltimore
- Agency: Roylance, Abrams, Berdo & Goodman, L.L.P.
- Main IPC: C07K16/28
- IPC: C07K16/28 ; C07K16/30 ; C12N15/113 ; C07K14/72
Abstract:
The present invention relates to novel androgen receptor splice variants (AR3, AR4, AR4b, AR5 and AR8) and variants and fragments thereof which have a role in the progression of androgen independent prostate cancer. The invention further relates to compositions and methods which can be used to identify and treat prostate cancer based on these novel androgen receptor splice variants, as well as methods for screening agents which modulate the activity and/or expression of the androgen receptor splice variants. Vectors, host cells and recombinant methods for producing the same and transgenic animals are also provided.
Public/Granted literature
- US20120156770A1 HUMAN ANDROGEN RECEPTOR ALTERNATIVE SPLICE VARIANTS Public/Granted day:2012-06-21
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