A steel pipe with a wall thickness over 30 mm is subjected to heat treatment of quenching and tempering using a temperature range of at least not less than 750° C. during the heating stage, makes it possible to obtain a heavy-wall seamless steel pipe having excellent toughness by resulting grain refinement. Quenching is by performing water cooling after heating the steel pipe to a temperature in the range of not less than 900° C. to not more than 1000° C. by using, as a heating means, induction heating at a frequency of not more than 200 Hz. Tempering is performed at a temperature in the range of not less than 500° C. to not more than 750° C. Preferably, after the heating by induction heating, a soaking treatment is performed in the temperature range of not less than 900° C. to not more than 1000° C. for 10 minutes or less followed by water cooling.