Invention Grant
US08846385B2 Method and means for producing high titer, safe recombinant lentivirus vectors
有权
用于生产高滴度，安全的重组慢病毒载体的方法和方法
- Patent Title: Method and means for producing high titer, safe recombinant lentivirus vectors
- Patent Title (中): 用于生产高滴度，安全的重组慢病毒载体的方法和方法
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Application No.: US11460136Application Date: 2006-07-26
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Publication No.: US08846385B2Publication Date: 2014-09-30
- Inventor: Luigi Naldini , Thomas Dull , Deborah A. Farson , Rochelle Witt
- Applicant: Luigi Naldini , Thomas Dull , Deborah A. Farson , Rochelle Witt
- Applicant Address: US CT Greenwich
- Assignee: GBP IP, LLC
- Current Assignee: GBP IP, LLC
- Current Assignee Address: US CT Greenwich
- Agent Jones Day
- Main IPC: C12N15/00
- IPC: C12N15/00 ; C07K14/005 ; C12N7/00 ; C12N15/86 ; C12N5/02 ; C12N5/07 ; C12N5/10 ; C12N5/16 ; C12P21/04 ; C12P21/06 ; A61K48/00 ; C07H21/02 ; C07H21/00 ; C07H21/04
Abstract:
Lentiviral vectors modified at the 5′ LTR or both the 5′ and 3′ LTR's are useful in the production of recombinant lentivirus vectors. Such vectors can be produced in the absence of a functional tat gene. Multiple transformation of the host cell with the vector carrying the transgene enhances virus production.
Public/Granted literature
- US20080286836A1 METHOD AND MEANS FOR PRODUCING HIGH TITER, SAFE RECOMBINANT LENTIVIRUS VECTORS Public/Granted day:2008-11-20
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