Invention Grant
US08846707B2 Substituted 2-hydroxy-4-(2-(phenylsulfonamido)acetamido)benzoic acid analogs as inhibitors of stat protein
有权
取代的2-羟基-4-（2-（苯基磺酰氨基）乙酰氨基）苯甲酸类似物作为stat蛋白的抑制剂
- Patent Title: Substituted 2-hydroxy-4-(2-(phenylsulfonamido)acetamido)benzoic acid analogs as inhibitors of stat protein
- Patent Title (中): 取代的2-羟基-4-（2-（苯基磺酰氨基）乙酰氨基）苯甲酸类似物作为stat蛋白的抑制剂
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Application No.: US13813916Application Date: 2011-08-02
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Publication No.: US08846707B2Publication Date: 2014-09-30
- Inventor: James Turkson , Patrick Gunning
- Applicant: James Turkson , Patrick Gunning
- Applicant Address: US FL Orlando CA Toronto, Ontario
- Assignee: Univeristy of Central Florida Research Foundation, Inc.,The Governing Council of the University of Toronto
- Current Assignee: Univeristy of Central Florida Research Foundation, Inc.,The Governing Council of the University of Toronto
- Current Assignee Address: US FL Orlando CA Toronto, Ontario
- Agency: Ballard Spahr LLP
- International Application: PCT/US2011/046340 WO 20110802
- International Announcement: WO2012/018868 WO 20120902
- Main IPC: A61K31/506
- IPC: A61K31/506 ; C07C311/29 ; C07C311/46 ; C07C311/42 ; C07D207/48 ; C07D215/36 ; C07C323/49 ; C07D211/96 ; A61K31/18 ; C07D401/04 ; C07D233/84 ; C07D211/26 ; C07C311/19 ; C07D213/42
Abstract:
In one aspect, the invention relates to substituted 2-hydroxy-4-(2-(phenylsulfonamido)acetamido)benzoic acid analogs, derivatives thereof, and related compounds, which are useful as inhibitors of STAT protein activity; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating disorders of uncontrolled cellular proliferation associated with a STAT protein activity dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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