Invention Grant
- Patent Title: Antibodies directed to GPNMB and uses thereof
- Patent Title (中): 针对GPNMB的抗体及其用途
-
Application No.: US13355366Application Date: 2012-01-20
-
Publication No.: US08846873B2Publication Date: 2014-09-30
- Inventor: Feng Xiao , Xiao-Chi Jia , Meina Liang , Orit Foord , Scott Klakamp , Kam Fai Tse , Vincent A. Pollack , Luca Rastelli , John Herrmann , Henri Lichenstein , Michael Jeffers , William LaRochelle , Gulshan Ara , Peter Mezes , Andrei Chapoval , Cyrus Karkaria , Michael Torgov , Juan Davagnino
- Applicant: Feng Xiao , Xiao-Chi Jia , Meina Liang , Orit Foord , Scott Klakamp , Kam Fai Tse , Vincent A. Pollack , Luca Rastelli , John Herrmann , Henri Lichenstein , Michael Jeffers , William LaRochelle , Gulshan Ara , Peter Mezes , Andrei Chapoval , Cyrus Karkaria , Michael Torgov , Juan Davagnino
- Applicant Address: US MA Needham US CA Fremont
- Assignee: Celldex Therapeutics, Inc.,Amgen Fremont, Inc.
- Current Assignee: Celldex Therapeutics, Inc.,Amgen Fremont, Inc.
- Current Assignee Address: US MA Needham US CA Fremont
- Agency: Mintz Levin Cohn Ferris Glovsky and Popeo, P.C.
- Agent Shovon Ashraf
- Main IPC: C07K16/30
- IPC: C07K16/30 ; C07K19/00 ; C07K16/28 ; A61K47/48 ; A61K39/00
Abstract:
The present invention provides fully human monoclonal antibodies that specifically bind to GPNMB, and uses thereof. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDRs) are provided. The present invention also provides immunoconjugates comprising anti-GPNMB antibodies and methods of using such immunoconjugates. The present invention further provides bi-specific antibodies comprising an anti-GPNMB antibody component and an anti-CD3 component, and methods of using such bispecific antibodies.
Public/Granted literature
- US20130022597A1 Antibodies Directed To GPNMB And Uses Thereof Public/Granted day:2013-01-24
Information query
