A system acquires images in the presence of a contrast agent of relatively long persistence using a synchronization processor, image acquisition device and imaging controller. The synchronization processor provides an image acquisition trigger signal for acquiring images at a particular point within both a cardiac and a respiratory cycle in response to signals representing cardiac and respiratory cycles. The image acquisition device includes an assembly comprising a radiation emitter and detector rotatable about a patient for acquiring images of a portion of patient anatomy at different angles. The imaging controller initiates acquisition of data representing multiple images in the presence of a contrast agent of relatively long persistence by repetitively, initiating rotation of the assembly to an angle, acquiring an image at the angle in response to the trigger signal and incrementally increasing the angle.