A multi-needle sewing machine is disclosed that includes a needle-bar case that supports needle bars; a needle-bar case transfer mechanism that transfers the needle-bar case to place a predetermined needle bar to a needle drop position; a thread guide member that is movable up and down, the thread guide member being provided with thread guide sections spaced by a predetermined distance and that guide a plurality of threads; a plurality of thread inlets that are provided at the needle-bar case, each thread inlet being uniquely associated with one of the thread guide sections and that introduces the threads guided by the thread guide sections toward the needle bars; and a lifting/lowering mechanism that moves the thread guide member up and down during transfer of the needle-bar ease and the thread inlets such that the thread guide sections and the associated thread inlets maintain a constant distance therebetween.