The invention concerns a system for the thermoregulation of dies for die-casting, dies for chill casting and the like. It comprises a tank (11) containing a cooling fluid; a primary hydraulic circuit (12) for a circulation of the cooling fluid from the tank to the die to be cooled and from this to the tank through a heat exchanger (SC); a secondary pneumatic circuit (13) connected to the primary hydraulic circuit (12) for the circulation of an aeriform fluid in the die to be cooled both in alternative, and in a mixed form with the liquid cooling fluid; and a pre-heating hydraulic circuit (112) integrated with the primary hydraulic circuit (12) and assigned to the production and circulation of a hot liquid fluid for pre-heating the die to be thermoregulated.