An in-wheel motor system capable of maximizing the efficiency in using a wheel space by improving a mounting structure thereof, the in-wheel motor system installed at a wheel of a vehicle to transmit a rotational force including an axle installed at the wheel of the wheel and rotating together with the wheel, an in-wheel motor mounted inside the wheel and provided with a rotor and a stator that are used to generate a rotational force to drive the wheel, the rotor, and the stator disposed to face each other while having an accommodation space thereinbetween, a cycloid decelerator installed at a center of the in-wheel motor, and provided with an output shaft to transmit a rotational force at a reduced speed from the in-wheel motor to the axle and an input shaft that passes through the in-wheel motor and rotates together with the rotor, a disc installed at one end portion of the input shaft that protrudes by passing through the in-wheel motor, and a disc brake configured to provide a braking force by pressing the disc, wherein the in-wheel motor and the cycloid decelerator are disposed in a space formed inside the wheel.