Invention Grant
- Patent Title: Engineering and optimization of improved systems, methods and enzyme compositions for sequence manipulation
- Patent Title (中): 改进系统的工程和优化，序列操纵的方法和酶组成
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Application No.: US14222930Application Date: 2014-03-24
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Publication No.: US08865406B2Publication Date: 2014-10-21
- Inventor: Feng Zhang , Fei Ran
- Applicant: The Broad Institute, Inc. , Massachusetts Institute of Technology
- Applicant Address: US MA Cambridge US MA Cambridge
- Assignee: The Broad Institute Inc.,Massachusetts Institute of Technology
- Current Assignee: The Broad Institute Inc.,Massachusetts Institute of Technology
- Current Assignee Address: US MA Cambridge US MA Cambridge
- Agency: Vedder Price P.C.
- Agent Thomas J. Kowalski; Deborah L. Lu
- Main IPC: C12Q1/68
- IPC: C12Q1/68 ; C12N15/85 ; C12N9/14 ; C12N9/22 ; C12N9/52 ; C12N15/00 ; C07H21/02 ; C07H21/04 ; A61K38/43 ; A61K38/46 ; A61K38/47
Abstract:
The invention provides for engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are compositions and methods related to components of a CRISPR complex particularly comprising a Cas ortholog enzyme.
Public/Granted literature
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