Invention Grant
US08865719B2 Substituted heterocycles and their use as allosteric modulators of nicotinic and GABAA receptors
有权
取代的杂环及其作为烟碱和GABA A受体的变构调节剂的用途
- Patent Title: Substituted heterocycles and their use as allosteric modulators of nicotinic and GABAA receptors
- Patent Title (中): 取代的杂环及其作为烟碱和GABA A受体的变构调节剂的用途
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Application No.: US13255781Application Date: 2010-03-09
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Publication No.: US08865719B2Publication Date: 2014-10-21
- Inventor: Timothy B. C. Johnstone , Derk J. Hogenkamp , Kelvin W. Gee
- Applicant: Timothy B. C. Johnstone , Derk J. Hogenkamp , Kelvin W. Gee
- Applicant Address: US CA Oakland
- Assignee: The Regents of the University of California
- Current Assignee: The Regents of the University of California
- Current Assignee Address: US CA Oakland
- Agency: TechLaw LLP
- Agent Richard H. Pagliery
- International Application: PCT/US2010/026645 WO 20100309
- International Announcement: WO2010/104843 WO 20100916
- Main IPC: A61K31/50
- IPC: A61K31/50 ; A61K31/501 ; C07D487/00
Abstract:
The present invention is related to heterocycles represented by a compound of Formula I that are novel allosteric modulators of α7 nAChRs and/or GABAA receptors. The invention also discloses the treatment of disorders that are responsive to enhancement of acetylcholine action on α7 nAChRs and negative allosteric modulation of GABAA receptors in a mammal by administering an effective amount of a compound of Formula I.
Public/Granted literature
- US20120077816A1 SUBSTITUTED HETEROCYCLES AND THEIR USE AS ALLOSTERIC MODULATORS OF NICOTINIC AND GABAA RECEPTORS Public/Granted day:2012-03-29
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