Invention Grant
- Patent Title: Antitumor agent for undifferentiated gastric cancer
- Patent Title (中): 用于未分化胃癌的抗肿瘤剂
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Application No.: US12439339Application Date: 2007-08-27
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Publication No.: US08865737B2Publication Date: 2014-10-21
- Inventor: Yuji Yamamoto , Tomohiro Matsushima , Akihiko Tsuruoka , Hiroshi Obaishi , Takayuki Nakagawa
- Applicant: Yuji Yamamoto , Tomohiro Matsushima , Akihiko Tsuruoka , Hiroshi Obaishi , Takayuki Nakagawa
- Applicant Address: JP Tokyo
- Assignee: Eisai R&D Management Co., Ltd.
- Current Assignee: Eisai R&D Management Co., Ltd.
- Current Assignee Address: JP Tokyo
- Agency: Fish & Richardson P.C.
- Priority: JP2006-230816 20060828
- International Application: PCT/JP2007/067088 WO 20070827
- International Announcement: WO2008/026748 WO 20080306
- Main IPC: A01N43/42
- IPC: A01N43/42 ; A61K31/47 ; C07D215/00
Abstract:
The present invention relates to a therapeutic agent represented by the General formula (I), or a pharmacologically acceptable salt thereof, or a solvate of the compound or the salt thereof: The therapeutic agent comprises a substance having the activity of inhibiting kinase activity of fibroblast growth factor receptor 2 (“FGFR2”). The therapeutic agent can be used for treating undifferentiated gastric cancer, and can also be used to treat organisms comprising a cell overexpressing FGFR2 or a cell expressing mutant FGFR2, or both. The present invention further relates to a pharmaceutical composition comprising an FGFR2 inhibitory and methods of treatment therewith. The present invention also relates to a method for predicting the effect of an FGFR2 inhibitory substance on a patient.
Public/Granted literature
- US20090264464A1 ANTITUMOR AGENT FOR UNDIFFERENTIATED GASTRIC CANCER Public/Granted day:2009-10-22
Information query
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