Invention Grant
- Patent Title: Intermediate compounds and processes for the preparation of quinoline derivatives such as Laquinimod sodium
- Patent Title (中): 用于制备喹啉衍生物如拉喹莫德钠的中间体化合物和方法
-
Application No.: US13989910Application Date: 2011-11-28
-
Publication No.: US08865742B2Publication Date: 2014-10-21
- Inventor: Ehud Marom , Michael Mizhiritskii , Shai Rubnov
- Applicant: Ehud Marom , Michael Mizhiritskii , Shai Rubnov
- Applicant Address: IL Ness Ziona
- Assignee: Mapi Pharma Ltd.
- Current Assignee: Mapi Pharma Ltd.
- Current Assignee Address: IL Ness Ziona
- Agency: Rothwell, Figg, Ernst & Manbeck, P.C.
- International Application: PCT/IL2011/050030 WO 20111128
- International Announcement: WO2012/070051 WO 20120531
- Main IPC: C07D221/02
- IPC: C07D221/02 ; C07D215/00 ; C07D215/12 ; C07D213/62 ; C07D213/78 ; A61K31/44 ; A01N43/40 ; A61K31/47 ; A01N43/42 ; C07C233/11 ; C07C63/70 ; C07D215/22 ; C07C233/55
Abstract:
The present invention relates to processes for the preparation of quinoline-3-carboxamide derivatives, such as sodium 5-chloro-3-(ethylphenylcarbamoyl)-1-methyl-2-oxo-1,2-dihydroquinolin-4-olate (Laquinimod sodium). The present invention further relates to intermediates formed in such processes.
Public/Granted literature
Information query
