Invention Grant
US08865875B2 Site-specific attachment of drugs or other agents to engineered antibodies with C-terminal extensions
有权
药物或其他药物与具有C末端延伸的工程抗体的位点特异性连接
- Patent Title: Site-specific attachment of drugs or other agents to engineered antibodies with C-terminal extensions
- Patent Title (中): 药物或其他药物与具有C末端延伸的工程抗体的位点特异性连接
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Application No.: US12674503Application Date: 2008-08-19
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Publication No.: US08865875B2Publication Date: 2014-10-21
- Inventor: Jie Liu , David King
- Applicant: Jie Liu , David King
- Applicant Address: US NJ Princeton
- Assignee: Medarex, L.L.C.
- Current Assignee: Medarex, L.L.C.
- Current Assignee Address: US NJ Princeton
- Agent Yuan Chao
- International Application: PCT/US2008/073569 WO 20080819
- International Announcement: WO2009/026274 WO 20090226
- Main IPC: C07K16/00
- IPC: C07K16/00 ; C07K16/46 ; A61K47/48 ; C07K16/28 ; C07K16/30
Abstract:
The present invention provides antibodies (e.g., IgG antibodies) having C-terminal cysteine-containing extensions that facilitate antibody conjugation to a partner molecule (e.g. a drug, toxin, marker molecule, protein, radioisotope, or other therapeutic agent). Methods of making, screening and selecting the antibodies of the invention are provided.
Public/Granted literature
- US20110280891A1 SITE-SPECIFIC ATTACHMENT OF DRUGS OR OTHER AGENTS TO ENGINEERED ANTIBODIES WITH C-TERMINAL EXTENSIONS Public/Granted day:2011-11-17
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