A dual compensation operational amplifier is suitable for use in an environment that experiences fluctuations in ambient energy levels. A dual compensation impedance can be determined to nullify or compensate for effects of an input offset voltage or an input bias current or both. Adjustments to the dual compensation impedance can be made based on calibration data for various environmental conditions so that the dual compensation impedance can be either pre-set for anticipated conditions in different target operational environments, or automatically adjusted in-situ. Target operational environments that may benefit from such a dual compensation impedance include remote areas that experience extreme or variable temperatures, high altitudes, space, or high radiation environments.