Method for implementing a software application in networked desktop virtualization environment, desktop virtualization environment including desktop virtualization server and desktop virtualization endpoint device, both in communication with one another over network. Method involves: structuring software with multiple internal elements and interfaces among them; installing first instance of software on desktop virtualization server, detecting characteristics of desktop virtualization server computer; in first instance of article of software, selectively enabling first set of internal software elements and disabling remaining internal software elements based on results of detecting on server computer; installing second instance of software on desktop virtualization client endpoint device; detecting characteristics of desktop virtualization endpoint device; in second instance of article of software, selectively enabling second set of internal software elements and disabling remaining internal software elements based on results of detecting on desktop virtualization client endpoint device; and establishing an association of second instance of software with first instance of software.