The combination of a) a dilator having: a tubular body with a length, an internal passage, and proximal and distal ends spaced in a lengthwise direction; and b) an elongate guide wire having a length and capable of being received in, and movable in a lengthwise direction within, the internal passage with the dilator and guide wire in operative relationship. The tubular body has a locally flexible length that allows a limited predetermined degree of bending of the tubular body at, or adjacent, the distal end of the tubular body to allow the dilator to conform to a curved guide wire shape.