A process and system is disclosed for optimizing a key parameter of a biomass feedstock that enhances bio-oil production. The process and system involves optimizing the values of the key parameter in multiple biomass feedstocks by regulating their feed rates and blending those feedstocks to produce a cumulative biomass feedstock with an optimal value for the key parameter. The key parameter in the biomass feedstocks is measured and the feed rates of the multiple biomass feedstocks are adjusted in order to produce a cumulative biomass feedstock exhibiting optimal values for the desired key parameter. The key parameters can include compositional properties, such as lignin content or mineral content, and/or fluidization properties of the biomass materials, such as density, particle cohesion force, or particle size.