Invention Grant
- Patent Title: Polyanionic multivalent macromolecules for intracellular targeting of proliferation and protein synthesis
- Patent Title (中): 聚阴离子多价大分子用于细胞内靶向增殖和蛋白质合成
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Application No.: US13576779Application Date: 2011-01-31
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Publication No.: US08877171B2Publication Date: 2014-11-04
- Inventor: Kai Licha , Michael Schirner , Pia Welker , Rainer Haag , Marie Weinhart , Florian Paulus
- Applicant: Kai Licha , Michael Schirner , Pia Welker , Rainer Haag , Marie Weinhart , Florian Paulus
- Applicant Address: DE Berlin
- Assignee: Mivenion GmbH
- Current Assignee: Mivenion GmbH
- Current Assignee Address: DE Berlin
- Agency: Millen, White, Zelano & Branigan P.C.
- Priority: EP10001104 20100203; EP10001655 20100218; EP10002121 20100302
- International Application: PCT/EP2011/000425 WO 20110131
- International Announcement: WO2011/095311 WO 20110811
- Main IPC: A61K31/74
- IPC: A61K31/74 ; C08G83/00 ; A61K49/00 ; A61K41/00 ; C07D487/22 ; A61K49/08 ; C07C237/14 ; C07D403/14 ; C07D403/10 ; C07D405/12 ; A61K47/48 ; A61K49/12 ; C07H21/02 ; A61K51/06
Abstract:
The present invention relates generally to methods and compositions for targeting of intracellular molecules involved in proliferation and protein synthesis of activated cells using polyanionic multivalent macromolecules. In particular aspect, multiple sulfate groups linked to polyol are specifically targeted to the cytoplasm and nucleus of proliferating and activated cells. The invention further comprises novel polyanionic macromolecular compounds and formulations.
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