Invention Grant
US08877207B2 Nanoparticles of cerium oxide targeted to an amyloid-beta antigen of Alzheimer's disease and associated methods
有权
靶向阿尔茨海默病淀粉样蛋白β抗原的氧化铈纳米颗粒及相关方法
- Patent Title: Nanoparticles of cerium oxide targeted to an amyloid-beta antigen of Alzheimer's disease and associated methods
- Patent Title (中): 靶向阿尔茨海默病淀粉样蛋白β抗原的氧化铈纳米颗粒及相关方法
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Application No.: US13184660Application Date: 2011-07-18
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Publication No.: US08877207B2Publication Date: 2014-11-04
- Inventor: Annamaria Cimini , Barbara D'Angelo , Soumen Das , Sudipta Seal
- Applicant: Annamaria Cimini , Barbara D'Angelo , Soumen Das , Sudipta Seal
- Applicant Address: US FL Orlando IT L'Aquila, Abruzzo
- Assignee: University of Central Florida Research Foundation, Inc.,University of l'Aquila
- Current Assignee: University of Central Florida Research Foundation, Inc.,University of l'Aquila
- Current Assignee Address: US FL Orlando IT L'Aquila, Abruzzo
- Agency: Beusse, Wolter, Sanks & Maire, P.A.
- Agent Timothy H. Van Dyke
- Main IPC: A61K9/14
- IPC: A61K9/14 ; A61K39/385 ; A61K38/00 ; A61K47/48 ; B82Y5/00
Abstract:
Disclosed is a composition immunologically targeted to Alzheimer's disease (AD), the composition containing amine functionalized nanoparticles of Cerium oxide coated with polyethylene glycol and bearing an antibody specific for an amyloid-beta antigen associated with AD. The invention also includes a medication manufactured with the targeted nanoceria particles and methods of treatment by administering the targeted nanoceria particles to patients in need thereof.
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