Invention Grant
US08877225B2 Controlled release copolymer formulation with improved release kinetics
有权
具有改进的释放动力学的控制释放共聚物制剂
- Patent Title: Controlled release copolymer formulation with improved release kinetics
- Patent Title (中): 具有改进的释放动力学的控制释放共聚物制剂
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Application No.: US12477805Application Date: 2009-06-03
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Publication No.: US08877225B2Publication Date: 2014-11-04
- Inventor: Richard L. Norton , Eric Dadey
- Applicant: Richard L. Norton , Eric Dadey
- Applicant Address: US CO Fort Collins
- Assignee: Tolmar Therapeutics, Inc.
- Current Assignee: Tolmar Therapeutics, Inc.
- Current Assignee Address: US CO Fort Collins
- Agency: Schwegman Lundberg & Woessner, P.A.
- Main IPC: A61F2/00
- IPC: A61F2/00 ; A61K47/30 ; A61P5/02 ; A61P23/00 ; A61P29/00 ; A61K38/31 ; A61K31/59 ; A61K9/00 ; A61K47/34 ; A61K38/09 ; A61K31/519 ; A61K47/22 ; A61K47/20 ; A61K47/10 ; A61K47/18

Abstract:
The present invention provides a constant release copolymer composition adapted for use in a controlled release formulation for a bioactive agent, such as a formulation adapted for implantation within a patient's body tissues as a depot to release the agent over a period of time, wherein the copolymer provides a substantially constant rate of release of the bioactive agent over the time period for which the depot persists in the body tissues. The copolymer includes a PLG copolymer and a PLG oligomer of about 5-10 kDa average molecular weight, which can lack free carboxylic acid groups. When the PLG copolymer is a low burst copolymer, the constant release copolymer composition is a low burst, constant release copolymer composition adapted for implantation in the body tissues of a mammal, wherein a substantially constant rate of release of the bioactive agent is achieved.
Public/Granted literature
- US20090325879A1 CONTROLLED RELEASE COPOLYMER FORMULATION WITH IMPROVED RELEASE KINETICS Public/Granted day:2009-12-31
Information query
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