Invention Grant
- Patent Title: Liposomes active in-vivo on neurodegenerative diseases
- Patent Title (中): 脂质体在体内对神经退行性疾病活跃
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Application No.: US13536851Application Date: 2012-06-28
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Publication No.: US08877236B2Publication Date: 2014-11-04
- Inventor: Massimo Masserini , Francesca Re , Giulio Sancini , Gianluigi Forloni , Mario Salmona
- Applicant: Massimo Masserini , Francesca Re , Giulio Sancini , Gianluigi Forloni , Mario Salmona
- Applicant Address: IT
- Assignee: Universita Degli Studi di Milano-Bicocca
- Current Assignee: Universita Degli Studi di Milano-Bicocca
- Current Assignee Address: IT
- Agency: Steinfl & Bruno LLP
- Main IPC: A61K9/127
- IPC: A61K9/127 ; A61P25/28 ; A61P25/00 ; A61K38/17
Abstract:
New liposomes are described, comprising: (i) phosphatidic acid and/or cardiolipin; (ii) apolipoprotein E (ApoE) or derivatives thereof. The so modified liposomes, administered systemically, obtain a dramatic in-vivo reduction of the amyloid plaque in the central nervous system, allowing an effective treatment of neurodegenerative diseases, in particular Alzheimer's disease.
Public/Granted literature
- US20140004172A1 LIPOSOMES ACTIVE IN-VIVO ON NEURODEGENERATIVE DISEASES Public/Granted day:2014-01-02
Information query
