Invention Grant
- Patent Title: Method for rapidly evaluating performance of short interfering RNA with novel chemical modifications
- Patent Title (中): 用新型化学修饰快速评估短干扰RNA性能的方法
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Application No.: US13515454Application Date: 2010-12-09
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Publication No.: US08877439B2Publication Date: 2014-11-04
- Inventor: Gabor Butora , Ian W. Davies , William Michael Flanagan , Wenlang Fu , Denise M. Kenski , Ning Qi
- Applicant: Gabor Butora , Ian W. Davies , William Michael Flanagan , Wenlang Fu , Denise M. Kenski , Ning Qi
- Applicant Address: US MA Cambridge
- Assignee: Sirna Therapeutics, Inc.
- Current Assignee: Sirna Therapeutics, Inc.
- Current Assignee Address: US MA Cambridge
- Agency: Lando & Anastasi, LLP
- International Application: PCT/US2010/059696 WO 20101209
- International Announcement: WO2011/084345 WO 20110714
- Main IPC: C12Q1/68
- IPC: C12Q1/68 ; C07H21/02
Abstract:
It is an object of the instant invention to provide a method for the rapid evaluation of novel sugar modifications to be used in siRNA synthesis including the rapid evaluation of chemical modification patterns within the siRNA to effectuate increased stability and ultimately increased efficacy of a siRNA therapeutic. It is a further object of the instant invention to provide novel nucleosides useful for siRNA therapy.
Public/Granted literature
- US20120252027A1 Method For Rapidly Evaluating Performance Of Short Interfering RNA With Novel Chemical Modifications Public/Granted day:2012-10-04
Information query
