Invention Grant
US08877452B2 Nitrite-reductase (NIRB) as potential anti-tubercular target and a method to detect the severity of tuberculosis disease
有权
亚硝酸还原酶（NIRB）作为潜在的抗结核病靶点和检测结核病严重程度的方法
- Patent Title: Nitrite-reductase (NIRB) as potential anti-tubercular target and a method to detect the severity of tuberculosis disease
- Patent Title (中): 亚硝酸还原酶（NIRB）作为潜在的抗结核病靶点和检测结核病严重程度的方法
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Application No.: US13778838Application Date: 2013-02-27
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Publication No.: US08877452B2Publication Date: 2014-11-04
- Inventor: Dhiman Sarkar
- Applicant: Dhiman Sarkar
- Applicant Address: IN
- Assignee: Council of Scientific and Industrial Research
- Current Assignee: Council of Scientific and Industrial Research
- Current Assignee Address: IN
- Agency: Schwegman, Lundberg & Woessner, P.A.
- Main IPC: G01N33/569
- IPC: G01N33/569 ; C12Q1/06
Abstract:
The present invention discloses functional nitrite reductase as a potential drug target for anti-tubercular drug development. The present invention also relates to the development of an easy method for identification of nitrite in clinical samples as well as its correlation with the severity of the disease. Presence of active as well as dormant/latent stages of Mycobacterium tuberculosis (MTB) could be identified from nitrite in clinical samples like sputum of potential TB patients.
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