Invention Grant
- Patent Title: Soluble and stable human 5-lipoxygenase
- Patent Title (中): 可溶性和稳定的人类5-脂氧合酶
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Application No.: US13700507Application Date: 2011-05-31
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Publication No.: US08877476B2Publication Date: 2014-11-04
- Inventor: Marcia E. Newcomer , Sue G. Bartlett , Nathaniel C. Gilbert
- Applicant: Marcia E. Newcomer , Sue G. Bartlett , Nathaniel C. Gilbert
- Applicant Address: US LA Baton Rouge
- Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
- Current Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
- Current Assignee Address: US LA Baton Rouge
- Agent Bonnie J. Davis; John H. Runnels
- International Application: PCT/US2011/038492 WO 20110531
- International Announcement: WO2011/153121 WO 20111208
- Main IPC: C12N9/02
- IPC: C12N9/02 ; C07H21/04 ; C12Q1/26
Abstract:
A soluble and stable form of 5-lipoxygenase (5-LOX) has been made, 5-Lox is the enzyme which initiates leukotriene biosynthesis by catalyzing the two-step transformation of arachidomc acid to leukotriene A4 (LTA4). The soluble and stable 5-LOX is suitable for a number of applications, including, but not limited to, high throughput screening of 5-LOX inhibitors, structural analysis of the enzyme's active site, designing inhibitors based on the three-dimensional structure of the enzyme's active site, and synthesis of LTA4. Using Stable-5-LOX, the crystal structure for 5-LOX has been resolved and the amino acids defining the active site determined.
Public/Granted literature
- US20130210052A1 A Soluble and Stable Human 5-Lipoxygenase Public/Granted day:2013-08-15
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