Invention Grant
US08877492B2 Compositions and methods for the production of alpha-herpesviruses
有权
用于生产α-疱疹病毒的组合物和方法
- Patent Title: Compositions and methods for the production of alpha-herpesviruses
- Patent Title (中): 用于生产α-疱疹病毒的组合物和方法
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Application No.: US13057788Application Date: 2009-08-11
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Publication No.: US08877492B2Publication Date: 2014-11-04
- Inventor: Simon Delagrave , Rachid Oubelaid , John Hamberger
- Applicant: Simon Delagrave , Rachid Oubelaid , John Hamberger
- Applicant Address: US MA Cambridge
- Assignee: Sanofi Pasteur Biologics, LLC
- Current Assignee: Sanofi Pasteur Biologics, LLC
- Current Assignee Address: US MA Cambridge
- Agency: Clark & Elbing LLP
- International Application: PCT/US2009/053407 WO 20090811
- International Announcement: WO2010/019572 WO 20100218
- Main IPC: C12N15/86
- IPC: C12N15/86 ; C12N5/00 ; C12N7/00 ; C12N15/63
Abstract:
The present invention relates to virus growth media that improve the yield of alpha-herpesviruses (e.g., HSV-2) grown in cell cultures. The growth media of the invention include two additives, a disaccharide and a lipid mixture, that can be added to serum-free or serum-enriched growth media to improve the efficiency of virus production. The invention further provides methods of producing alpha-herpesviruses (e.g., HSV-2) in such growth media.
Public/Granted literature
- US20110201087A1 Compositions and Methods for the Production of Alpha-Herpesviruses Public/Granted day:2011-08-18
Information query
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